1. With 'Coloretto' Marburg offers wallpapers for every room and every taste. The collection shows a best-of of the most popular designs and colours of recent years. It is timeless and universally applicable.
2. Game play in Coloretto is simple: Either draw a card to play to a row, or take a row of cards to add them to your collection. A row can have at most three cards, so at some point everyone is forced to take a row. Once all the rows have been claimed, players start a new round, drawing or taking once again.
3. Game play in Coloretto is simple: Either draw a card to play to a row, or take a row of cards to add them to your collection. A row can have at most three cards, so at some point everyone is forced to take a row. Once all the rows have been claimed, players start.
4. About Like a Chameleon, a player may change his color many times during the game. However, players who change colors too often will not do well and may even earn minus points for doing so. This means that a player must wait for the proper time and place to make the change, but do.

The players draw cards from a card supply in the middle of the table. During the game, the players try to specialize in a few colors, as at the end of the game, a player can score plus points for only 3 colors; the rest score minus points. The more cards a player has of a color, the more points he scores. The player with the most points wins.

On December 19, 2018, the Food and Drug Administration granted accelerated approval to pembrolizumab (KEYTRUDA®, Merck & Co. Inc.) for adult and pediatric patients with recurrent locally advanced or metastatic Merkel cell carcinoma (MCC).

Approval was based on Cancer Immunotherapy Trials Network protocol 9 (CITN-09), also known as KEYNOTE-017 (NCT02267603), a multicenter, non-randomized, open-label trial that enrolled 50 patients with recurrent locally advanced or metastatic MCC who had not received prior systemic therapy for their advanced disease. Patients received pembrolizumab 2 mg/kg every 3 weeks.

The major efficacy outcome measures were overall response rate (ORR) and response duration assessed by blinded independent central review per RECIST 1.1. The ORR was 56% (95% CI: 41, 70) with a complete response rate of 24%. The median response duration was not reached. Among the 28 patients with responses, 96% had response durations of greater than 6 months and 54% had response durations of greater than 12 months.

The most common adverse reactions of pembrolizumab reported in at least 20% of patients who received pembrolizumab as a single agent were fatigue, musculoskeletal pain, decreased appetite, pruritus, diarrhea, nausea, rash, pyrexia, cough, dyspnea, constipation, pain, and abdominal pain.

The recommended pembrolizumab dose for MCC is 200 mg administered as a 30-minute intravenous infusion every 3 weeks for adults; 2 mg/kg (to a maximum of 200 mg) administered as a 30-minute intravenous infusion every 3 weeks for patients less than 18 years of age (pediatric patients).

View full prescribing information for KEYTRUDA.

This indication is approved under accelerated approval based on tumor response rate and durability of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in the confirmatory trials.

FDA granted this application priority review and Breakthrough Therapy designation. A description of FDA expedited programs is in the Guidance for Industry: Expedited Programs for Serious Conditions-Drugs and Biologics.

Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDA’s MedWatch Reporting System or by calling 1-800-FDA-1088.

Follow the Oncology Center of Excellence on Twitter @FDAOncology.

Check out recent approvals at the OCE’s podcast, Drug Information Soundcast in Clinical Oncology (D.I.S.C.O.).

On the surface this is a quite random card collecting game with the twist that only the three best piles of a certain color you gather are scored positive, all the rest are scored negative. However, after a few rounds you realise there are so much more to this game, and after a few more rounds you see the wolf behind the sheep mask.

This game offers so many more interesting choices than people realise. The rules themselves are very easy (learned in 3 minutes), on the table are one card pile spot for each player, and each round all players must grab one pile. On your turn you can either grab one of the piles containing at least one card or draw a card from the stack and add it to any pile with fewer than three cards (no pile may contain more than 3 cards at any time). Any player that have grabbed a pile are temporarily out while there are unclaimed piles. When all piles have been taken, the one grabbing the last one start a new round, and this goes on until you reach a “last Round” card placed a few cards from the bottom of the deck. Easy huh?

There are two different choices that must be made in the game:

Coloretto Ink Cartridge

1. Grab a pile or draw a card?
Knowing when to grab a pile instead of drawing is hard. In general you score more points the more cards you get, but obviously you just want to get away from some rounds with as few wounds as you can. Yes, sometimes players lose points after a round if they are unlucky. Also, being able to see what pile you should grab can be a bit tricky, since you don’t want the highest score possible, you want as high score as possible COMPARED to the other players. Sometimes you can grab a pile that give you slightly fewer points but creates a mess for your competitors. And sometimes you simply have to take one for the team since a specific pile is too good for another player and the collective can simply not allow that to happen.

Coloretto Game

2. When picking a card, knowing where to put it
This is the real engine in the game, observing what piles are of what interest to the other players and increasing your own options at the same time as poisioning their opportunities. Also, realising the consequences of your actions so that you do not end up with a lousy pile yourself is really important.

Coloretto Ink Reviews

All in all this is a great game, and everyone we’ve introduced to Coloretto have liked it, both gamers and non-gamers. I highly recommend this for everyone. Don’t let the simple rules fool you, this is a great game with hidden qualities. But yes, luck is a pretty large factor in Coloretto, that cannot be denied. 😉